The inverse association between magnesium intake and cerebral infarction was stronger in men younger than 60 years (relative risk, 0.76 95% confidence interval, 0.64-0.89 P for interaction = .02). The multivariate relative risk of cerebral infarction was 0.85 (95% confidence interval, 0.76-0.97 P for trend = .004) for men in the highest quintile of magnesium intake compared with those in the lowest quintile. Results After adjustment for age and cardiovascular risk factors, a high magnesium intake was associated with a statistically significant lower risk of cerebral infarction but not with intracerebral or subarachnoid hemorrhages. During a mean follow-up of 13.6 years (1985-2004), 2702 cerebral infarctions, 383 intracerebral hemorrhages, and 196 subarachnoid hemorrhages were identified in the national registries.
Dietary intake was assessed at baseline using a detailed and validated food frequency questionnaire.
Methods We examined the relationship of dietary magnesium, calcium, potassium, and sodium intake with risk of stroke in a cohort of 26 556 Finnish male smokers, aged 50 to 69 years, who were free from stroke at baseline. However, prospective data relating intake of these minerals to risk of stroke are inconsistent. Shared Decision Making and Communicationīackground A high intake of magnesium, calcium, and potassium and a low intake of sodium have been hypothesized to reduce the risk of stroke.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.